Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel

Delivery of drugs and nanomedicines to tumors is often heterogeneous insufficient and, thus, limited efficacy. Microbubbles in combination with ultrasound have been found improve delivery tumors, enhancing accumulation penetration. We used a subcutaneous prostate cancer xenograft model mice investigate the effect free nanoparticle-encapsulated cabazitaxel microbubbles lipid shell or nanoparticles. Sonopermeation reduced tumor growth prolonged survival (26%–100%), whether drug was co-injected lipid-shelled nanoformulation nanoparticle-shelled microbubbles. Coherently improved therapeutic response, we enhanced uptake nanoparticles directly after treatment that lasted several weeks (2.3 × –15.8 increase). Neither cavitation dose nor total could explain variation within groups, emphasizing need for better understanding biology mechanisms involved ultrasound-mediated treatment.